"Deadly Nightshade" redirects here. For the 1953 British film, see Deadly Nightshade (film).
Atropa belladonna, commonly known as belladonna or deadly nightshade, is a perennial herbaceous plant in the nightshade family Solanaceae, which includes tomatoes, potatoes, and eggplant (aubergine). It is native to Europe, North Africa, and Western Asia. Its distribution extends from Great Britain in the west to western Ukraine and the Iranian province of Gilan in the east. It is also naturalised or introduced in some parts of Canada and the United States.
The foliage and berries are extremely toxic when ingested, containing tropane alkaloids. These toxins include atropine, scopolamine and hyoscyamine, which cause delirium and hallucinations, and are also used as pharmaceutical anticholinergics. These tropane alkaloids appear to be common in the Solanaceae family, as they are also present in plants of the Brugmansia, Datura and Hyoscyamus genera, of the same family but in different subfamilies and tribes to the nightshade.
It has a long history of use as a medicine, cosmetic, and poison. Before the Middle Ages, it was used as an anesthetic for surgery; the ancient Romans used it as a poison — the Roman empresses Livia Drusilla and Agrippina the Younger both were rumored to have used it for murder; and, predating this, it was used to make poison-tipped arrows. The genus name Atropa comes from Atropos ("unable to be turned aside"), one of the three Fates from Greek mythology, who cut the thread of life after her sisters had spun and measured it. The name belladonna is derived from Italian for "beautiful woman", as during the Renaissance, the herb was used in eyedrops by women to dilate the pupils of the eyes to make them appear seductive.
Atropa belladonna is a branching herbaceous perennial rhizomatous hemicryptophyte, often growing as a subshrub from a fleshy rootstock. Plants grow to 2 m (6.6 ft) tall with ovate leaves 18 cm (7.1 in) long. The bell-shaped flowers are dull purple with green tinges and faintly scented. The fruits are berries, which are green, ripening to a shiny black, and approximately 1.5 cm (0.59 in) in diameter. The berries are sweet and are consumed by animals that disperse the seeds in their droppings, even though they contain toxic alkaloids. (See Toxicity) There is a pale-yellow flowering form called Atropa belladonna var. lutea with pale yellow fruit.
In Britain it is native only on calcareous soils, on disturbed ground, field margins, hedgerows and open woodland. More widespread as an alien, it is often a relic of cultivation as a medicinal herb. Seed is spread mainly by birds.
Atropa belladonna is rarely used in gardens, but, when grown, it is usually for its large upright habit and showy berries. Germination of the small seeds is often difficult, due to hard seed coats that cause seed dormancy. Germination takes several weeks under alternating temperature conditions, but can be sped up with the use of gibberellic acid. The seedlings need sterile soil to prevent damping off and resent root disturbance during transplanting.
Atropa belladonna is in the nightshade family (Solanaceae), which it shares with potatoes, tomatoes, eggplants, jimsonweed, tobacco, wolfberry, and chili peppers. The common names for this species include belladonna, deadly nightshade, divale, dwale, banewort, devil's berries, death cherries, beautiful death, devil's herb, great morel, and dwayberry.
The name Atropa belladonna was published by Carl Linnaeus in Species Plantarum in 1753. Atropa is derived from the name of the Greek goddess Atropos ('she who may not be turned aside' i.e. 'the inflexible' or 'the implacable')—one of the three Greek fates or destinies who would determine the course of a man's life by the weaving of threads that symbolized his birth, the events in his life, and finally his death, with Atropos cutting these threads to mark the last of these. The name "belladonna" comes from the Italian language, meaning 'beautiful lady'; originating either from its usage as a cosmetic to beautify pallid skin, or more probably, from its usage to increase the pupil size in women.
Belladonna is one of the most toxic plants found in the Eastern Hemisphere, and its use by mouth increases risk in numerous clinical conditions, such as complications of pregnancy, cardiovascular diseases, gastrointestinal disorders, and psychiatric disorders, among others. All parts of the plant contain tropane alkaloids. Roots have up to 1.3%, leaves 1.2%, stalks 0.65%, flowers 0.6%, ripe berries 0.7%, and seeds 0.4% tropane alkaloids; leaves reach maximal alkaloid content when the plant is budding and flowering, roots are most poisonous in the end of the plant's vegetation period. Belladonna nectar is transformed by bees into honey that also contains tropane alkaloids. The berries pose the greatest danger to children because they look attractive and have a somewhat sweet taste. The root of the plant is generally the most toxic part, though this can vary from one specimen to another.
The active agents in belladonna, atropine, hyoscine (scopolamine), and hyoscyamine, have anticholinergic properties. The symptoms of belladonna poisoning include dilated pupils, sensitivity to light, blurred vision, tachycardia, loss of balance, staggering, headache, rash, flushing, severely dry mouth and throat, slurred speech, urinary retention, constipation, confusion, hallucinations, delirium, and convulsions. In 2009, A. belladonna berries were mistaken for blueberries by an adult woman; the six berries she ate were documented to result in severe anticholinergic syndrome. The plant's deadly symptoms are caused by atropine's disruption of the parasympathetic nervous system's ability to regulate involuntary activities, such as sweating, breathing, and heart rate. The antidote for belladonna poisoning is an anticholinesterase (such as physostigmine or pilocarpine), the same as for atropine.
Atropa belladonna is also toxic to many domestic animals, causing narcosis and paralysis. However, cattle and rabbits eat the plant seemingly without suffering harmful effects. In humans, its anticholinergic properties will cause the disruption of cognitive capacities, such as memory and learning.
Belladonna cultivation is legal in Southern and Eastern Europe, Pakistan, North America, and Brazil. All parts of the belladonna plant can be cultivated, bought, kept, and distributed (sold, traded or given) without a legal license or medical prescription in the United States. Sales of belladonna in the United States conform to US supplement laws or are regulated by the FDA. Belladonna leaves and roots can be bought with a medical prescription in pharmacies throughout Germany.
The common name belladonna originates from its historic use by women, as bella donna is Italian for "beautiful lady". Drops prepared from the belladonna plant were used to dilate women's pupils, an effect considered to be attractive and seductive. Belladonna drops act as a muscarinic antagonist, blocking receptors in the muscles of the eye that constrict pupil size. Belladonna is currently rarely used cosmetically, as it carries the adverse effects of causing minor visual distortions, inability to focus on near objects, and increased heart rate. Prolonged usage was reputed to cause blindness.
Scientific evidence to recommend the use of A. belladonna in its natural form for any condition is insufficient, although some of its components, in particular l-atropine, which was purified from belladonna in the 1830s, have accepted medical uses. Donnatal is a prescription pharmaceutical, approved in the United States by the FDA, that combines natural belladonna alkaloids in a specific, fixed ratio with phenobarbital to provide peripheral anticholinergic/antispasmodic action and mild sedation. According to its labeling, it is possibly effective for use as adjunctive therapy in the treatment of irritable bowel syndrome (irritable colon, spastic colon, mucous colitis) and acute enterocolitis.
Belladonna has been used in herbal medicine for centuries as a pain reliever, muscle relaxer, and anti-inflammatory, and to treat menstrual problems, peptic ulcer disease, histaminic reaction, and motion sickness. At least one 19th-century eclectic medicine journal explained how to prepare a belladonna tincture for direct administration.
Belladonna preparations are used in homeopathy as alternative medicine treatments for various conditions. In homeopathic practices, belladonna was prescribed by German physician Samuel Hahnemann as a topical medication for inflammation and pain. In the form of Doktor Koster's Antigaspills, belladonna was a homeopathic medication for upset stomach and excessive flatulence. There is insufficient scientific evidence justifying the use of belladonna for these or any other clinical disorders.
In 2010 and 2016, the US Food and Drug Administration warned consumers against the use of homeopathic teething tablets and gels containing belladonna as used for infants and children, stating that the products may be toxic, causing "seizures, difficulty breathing, lethargy, excessive sleepiness, muscle weakness, skin flushing, constipation, difficulty urinating, or agitation".
Atropa belladonna and related plants, such as Datura stramonium (commonly known as jimson weed), have occasionally been used as recreational drugs because of the vivid hallucinations and delirium they produce. These hallucinations are most commonly described as very unpleasant, and recreational use is considered extremely dangerous because of the high risk of unintentional fatal overdose. The main psychoactive ingredients are the alkaloids scopolamine, and to a lesser extent, hyoscyamine. The effects of atropine on the central nervous system include memory disruption, which may lead to severe confusion. The major effects of belladonna consumption last for three to four hours; visual hallucinations can last for three to four days, and some negative aftereffects are preserved for several days.
The tropane alkaloids of A. belladonna were used as poisons, and early humans made poisonous arrows from the plant. In Ancient Rome, it was used as a poison by Agrippina the Younger, wife of Emperor Claudius on the advice of Locusta, a woman who specialized in poisons, and Livia, who is rumored to have used it to kill her husband Emperor Augustus.
Main article: Flying ointment
In the past, witches were believed to use a mixture of belladonna, opium poppy and other plants, typically poisonous (such as monkshood and poison hemlock), in flying ointment, which they allegedly applied to help them fly to gatherings with other witches or to experience bacchanalian carousal. Carlo Ginzburg and others have argued that flying ointments were preparations meant to encourage hallucinatory dreaming; a possible explanation for the inclusion of belladonna and opium poppy in flying ointments concerns the known antagonism between tropane alkaloids of belladonna (scopolamine) and opiate alkaloids in the opium poppy, Papaver somniferum (to be specific, morphine), which produces a dream-like waking state (hypnagogia) or potentiated dreams while the user is asleep. This antagonism was known in folk medicine, discussed in traditional medicine formularies. The belladonna herb was also notable for its unpredictable effects from toxicity.
Among the ancient folk traditions of the Romanian (Moldavian) / Ukrainian region of Bukovina in the Carpathians is the ritual for a Bukovinian girl to enhance her attractiveness by making an offering to deadly nightshade. She entered the fields on a Sunday in Shrovetide, clad in her Sunday best, accompanied by her mother and bringing a bag of bread, salt, and brandy. She would dig up a deadly nightshade root and leave the three offerings in its place. As she returned home, she carried the root on the top of her head. On the way both to and from home, she avoided all quarrels and arguments. If asked by anyone on the way back what she was taking home, she would not divulge the truth or the spell would break.
Solanaceae Atropa belladonna L. Species Plantarum 2 1753 "Habitat in Austriae, Angliae montibus sylvosis."