Before humans went into space in the 1960s, several other animals were launched into space, including numerous other primates, so that scientists could investigate the biological effects of space travel. The United States launched flights containing primate passengers primarily between 1948 and 1961 with one flight in 1969 and one in 1985. France launched two monkey-carrying flights in 1967. The Soviet Union and Russia launched monkeys between 1983 and 1996. Most primates were anesthetized before lift-off. Overall thirty-two monkeys flew in the space program; none flew more than once. Numerous backup monkeys also went through the programs but never flew. Monkeys and apes from several species were used, including rhesus macaque, crab-eating macaque, squirrel monkeys, pig-tailed macaques, and chimpanzees.
Albert was followed by Albert II who survived the V-2 flight but died on impact on June 14, 1949, after a parachute failure. Albert II became the first monkey and the first primate in space as his flight reached 134 km (83 mi) – past the Kármán line of 100 km taken to designate the beginning of space. Albert III died at 35,000 feet (10.7 km) in an explosion of his V2 on September 16, 1949. Albert IV, on the last monkey V-2 flight, died on impact on December 8 that year after another parachute failure. His flight reached 130.6 km. Alberts, I, II, and IV were rhesus macaque while Albert III was a crab-eating macaque.
Monkeys later flew on Aerobee rockets. On April 18, 1951, a monkey, possibly called Albert V, died due to parachute failure. Yorick, also called Albert VI, along with 11 mouse crewmates, reached 236,000 ft (72 km, 44.7 mi) and survived the landing, on September 20, 1951, the first monkey to do so (the dogs Dezik, and Tsygan had survived a trip to space in July of that year), although he died 2 hours later. Two of the mice also died after recovery; all of the deaths were thought to be related to stress from overheating in the sealed capsule in the New Mexico sun while awaiting the recovery team. Albert VI's flight surpassed the 50-mile boundary the U.S. used for spaceflight but was below the international definition of space. Patricia and Mike, two cynomolgus monkeys, flew on May 21, 1952, and survived, but their flight was only to 26 kilometers.
On May 28, 1959, aboard the JUPITER AM-18, Able, a rhesus macaque, and Miss Baker, a squirrel monkey flew a successful mission. Able was born at the Ralph Mitchell Zoo in Independence, Kansas. They travelled in excess of 16,000 km/h, and withstood 38 g (373 m/s2). Able died June 1, 1959, while undergoing surgery to remove an infected medical electrode, from a reaction to the anesthesia. Baker became the first monkey to survive the stresses of spaceflight and the related medical procedures. Baker died November 29, 1984, at the age of 27 and is buried on the grounds of the United States Space & Rocket Center in Huntsville, Alabama. Able was preserved, and is now on display at the Smithsonian Institution's National Air and Space Museum. Their names were taken from the 1943–1955 US military phonetic alphabet.
On December 4, 1959, Sam, a rhesus macaque, flew on the Little Joe 2 in the Mercury program to 53 miles high. Miss Sam, also a rhesus macaque, followed in 1960, on Little Joe 1B although her flight was only to 8 mi (13 km) in a test of emergency procedures. Ham and Enos also flew in the Mercury program but they were chimpanzees. The names 'Sam' and 'Ham' were acronyms. Sam was named in homage to the School of Aerospace Medicine at Brooks Air Force Base in San Antonio, Texas. The name 'Ham' was taken from Holloman Aerospace Medicine at Holloman Air Force Base, New Mexico.
France launched a pig-tailed macaque named Martine on a Vesta rocket on March 7, 1967, and another named Pierette on March 13. These suborbital flights reached 243 km (151 mi) and 234 km (145 mi), respectively. Martine became the first monkey to survive more than a couple of hours after flying above the international definition of the edge of space. (Ham and Enos, launched earlier by the United States, had been chimpanzees).
The Soviet /Russian space program used only rhesus macaques in its Bion satellite program in 1980s and 1990s. The names of the monkeys began with sequential letters of the Russian alphabet (А, Б, В, Г, Д, Е, Ё, Ж, З...). The animals all survived their missions but for a single fatality in post-flight surgery, after which the program was cancelled.
On December 23, 1969, as part of the 'Operación Navidad' (Operation Christmas), Argentina launched Juan (a tufted capuchin, native to Argentina's Misiones Province) using a two-stage Rigel 04 rocket. It ascended perhaps up to 82 kilometers and then was recovered successfully. Other sources give 30, 60 or 72 kilometers. All of these are below the international definition of space (100 km). Later, on February 1, 1970, the experience was repeated with a female monkey of the same species using a X-1 Panther rocket. Although it reached a higher altitude than its predecessor, it was lost after the capsule's parachute failed.
The PRC spacecraft Shenzhou 2 launched on January 9, 2001. Inside the reentry module (precise information is lacking due to the secrecy surrounding China's space program) a monkey, dog, and rabbit rode aloft in a test of the spacecraft's life support systems. The SZ2 reentry module landed in Inner Mongolia on January 16. No images of the recovered capsule appeared in the press, leading to the widespread inference that the flight ended in failure. According to press reports citing an unnamed source, a parachute connection malfunction caused a hard landing.
On January 28, 2013, AFP and Sky News reported that Iran had sent a monkey in a "Pishgam" rocket to a height of 72 miles (116 km) and retrieved "shipment". Iranian media gave no details on the timing or location of the launch, while details that were reported raised questions about the claim. Pre-flight and post-flight photos clearly showed different monkeys. The confusion was due to the publishing of an archive photo from 2011 by the Iranian Student News Agency (ISNA). According to Jonathan McDowell, a Harvard astronomer, "They just mixed that footage with the footage of the 2013 successful launch."
On December 14, 2013, AFP and BBC reported that Iran again sent a monkey to space and safely returned it. Rhesus macaque Aftab (2013.01.28) and Fargam (2013.12.14) were each launched separately into space and safely returned. Researchers continue to study the effects of the space trip on their offspring.